Gut barrier dysfunction refers to a condition in which the lining of the gastrointestinal tract becomes compromised, allowing harmful substances such as toxins, bacteria, and antigens to pass through the intestinal barrier and enter the bloodstream. This can lead to inflammation, immune system activation, and various health problems, including gastrointestinal disorders, autoimmune diseases, and metabolic conditions. Research in this area focuses on understanding the mechanisms underlying gut barrier dysfunction, identifying potential risk factors, and developing strategies to prevent or treat this condition. Studies often explore the impact of diet, chronic stress, medications, and genetic factors on gut health, as well as the role of gut microbiota in maintaining intestinal barrier integrity. Ultimately, improving our understanding of gut barrier dysfunction may lead to novel therapeutic approaches for a range of health issues related to gastrointestinal health.